- Editorial Advisory Board
- Dedication
- Preface
- Acknowledgments
- Contributors
- Chapter 1 The Next Decade of Research in the Basic Mechanisms of the Epilepsies
- Chapter 2 Herbert H. Jasper and the Basic Mechanisms of the Epilepsies
- Chapter 3 Why—and How—Do We Approach Basic Epilepsy Research?
- Chapter 4 Voltage-Gated Na+ Channels
- Chapter 5 Potassium Channels (Including KCNQ) and Epilepsy
- Chapter 6 Voltage-Gated Calcium Channels in Epilepsy
- Chapter 7 Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy
- Chapter 8 Phasic GABAA-Mediated Inhibition
- Chapter 9 Tonic GABAA Receptor–Mediated Signaling in Epilepsy
- Chapter 10 Glutamatergic Mechanisms Related to Epilepsy
- Chapter 11 Glutamate Receptors in Epilepsy
- Chapter 12 Plasticity of Glutamate Synaptic Mechanisms
- Chapter 13 Neuronal Synchronization and Thalamocortical Rhythms during Sleep, Wake, and Epilepsy
- Chapter 14 Limbic Network Synchronization and Temporal Lobe Epilepsy
- Chapter 15 Imaging of Hippocampal Circuits in Epilepsy
- Chapter 16 Normal and Pathological High-Frequency Oscillations
- Chapter 17 Interictal Epileptiform Discharges in Partial Epilepsy
- Chapter 18 GABAA Receptor Function in Typical Absence Seizures
- Chapter 19 GABAB Receptor and Absence Epilepsy
- Chapter 20 Brainstem Networks
- Chapter 21 On the Basic Mechanisms of Infantile Spasms
- Chapter 22 Fast Oscillations and Synchronization Examined with In Vitro Models of Epileptogenesis
- Chapter 23 Computer Modeling of Epilepsy
- Chapter 24 Traumatic Brain Injury and Posttraumatic Epilepsy
- Chapter 25 Head Trauma and Epilepsy
- Chapter 26 Fever, Febrile Seizures, and Epileptogenesis
- Chapter 27 Role of Blood-Brain Barrier Dysfunction in Epileptogenesis
- Chapter 28 Cell Death and Survival Mechanisms after Single and Repeated Brief Seizures
- Chapter 29 Programmed Necrosis after Status Epilepticus
- Chapter 30 Histopathology of Human Epilepsy
- Chapter 31 The Time Course and Circuit Mechanisms of Acquired Epileptogenesis
- Chapter 32 Mossy Fiber Sprouting in the Dentate Gyrus
- Chapter 33 Kainate and Temporal Lobe Epilepsies
- Chapter 34 Abnormal Dentate Gyrus Network Circuitry in Temporal Lobe Epilepsy
- Chapter 35 Alterations in Synaptic Function in Epilepsy
- Chapter 36 Seizure-Induced Formation of Basal Dendrites on Granule Cells of the Rodent Dentate Gyrus
- Chapter 37 Perturbations of Dendritic Excitability in Epilepsy
- Chapter 38 Neurogenesis and Epilepsy
- Chapter 39 Temporal Lobe Epilepsy and the BDNF Receptor, TrkB
- Chapter 40 Alterations in the Distribution of GABAA Receptors in Epilepsy
- Chapter 41 GABAA Receptor Plasticity during Status Epilepticus
- Chapter 42 Plasticity of GABAA Receptors Relevant to Neurosteroid Actions
- Chapter 43 GABAA Receptor Plasticity in Alcohol Withdrawal
- Chapter 44 Regulation of GABAA Receptor Gene Expression and Epilepsy
- Chapter 45 Chloride Homeostasis and GABA Signaling in Temporal Lobe Epilepsy
- Chapter 46 Astrocytes and Epilepsy
- Chapter 47 Astrocyte Dysfunction in Epilepsy
- Chapter 48 Glia–Neuron Interactions in Ictogenesis and Epileptogenesis
- Chapter 49 Glia–Neuron Interactions
- Chapter 50 Genetic Epidemiology and Gene Discovery in Epilepsy
- Chapter 51 Strategies for Studying the Epilepsy Genome
- Chapter 52 Sodium Channel Mutations and Epilepsy
- Chapter 53 Potassium Channelopathies of Epilepsy
- Chapter 54 The Voltage-Gated Calcium Channel and Absence Epilepsy
- Chapter 55 Mutated GABAA Receptor Subunits in Idiopathic Generalized Epilepsy
- Chapter 56 The GABAAγ2(R43Q) Mouse Model of Human Genetic Epilepsy
- Chapter 57 GABAA Receptor Subunit Mutations and Genetic Epilepsies
- Chapter 58 Nicotinic Acetylcholine Receptor Mutations
- Chapter 59 Gene Interactions and Modifiers in Epilepsy
- Chapter 60 Rare Genetic Causes of Lissencephaly May Implicate Microtubule-Based Transport in the Pathogenesis of Cortical Dysplasias
- Chapter 61 The Generation of Cortical Interneurons
- Chapter 62 Genes in Infantile Epileptic Encephalopathies
- Chapter 63 Developing Models of Aristaless-Related Homeobox Mutations
- Chapter 64 Haploinsufficiency of STXBP1 and Ohtahara Syndrome
- Chapter 65 mTOR and Epileptogenesis in Developmental Brain Malformations
- Chapter 66 Major Susceptibility Genes for Common Idiopathic Epilepsies
- Chapter 67 Myoclonin1/EFHC1 in Cell Division, Neuroblast Migration, and Synapse/Dendrite Formation in Juvenile Myoclonic Epilepsy
- Chapter 68 Progressive Myoclonus Epilepsy of Lafora
- Chapter 69 Progressive Myoclonus Epilepsy
- Chapter 70 GABRB3, Epilepsy, and Neurodevelopment
- Chapter 71 Pathophysiology of Epilepsy in Autism Spectrum Disorders
- Chapter 72 Cognitive and Behavioral Comorbidities of Epilepsy
- Chapter 73 Migraine and Epilepsy—Shared Mechanisms within the Family of Episodic Disorders
- Chapter 74 Neurobiology of Depression as a Comorbidity of Epilepsy
- Chapter 75 Calcium Channel α2δ Subunits in Epilepsy and as Targets for Antiepileptic Drugs
- Chapter 76 Targeting SV2A for Discovery of Antiepileptic Drugs
- Chapter 77 Neurosteroids—Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy
- Chapter 78 Mechanisms of Ketogenic Diet Action
- Chapter 79 Deep Brain Stimulation for Epilepsy
- Chapter 80 Animal Models for Evaluating Antiepileptogenesis
- Chapter 81 Strategies for Antiepileptogenesis
- Chapter 82 Neonatal Seizures and Neuronal Transmembrane Ion Transport
- Chapter 83 Antiepileptogenesis, Plasticity of AED Targets, Drug Resistance, and Targeting the Immature Brain
- Chapter 84 Drug Resistance
- Chapter 85 Neural Stem Cell Therapy for Temporal Lobe Epilepsy
- Chapter 86 Embryonic Stem Cell Therapy for Intractable Epilepsy
- Chapter 87 Cell Therapy Using GABAergic Neural Progenitors
- Chapter 88 Reversing Disorders of Neuronal Migration and Differentiation in Animal Models
- Chapter 89 Gene Therapy of Focal-Onset Epilepsy Using Adeno-Associated Virus Vector-Mediated Overexpression of Neuropeptide Y
- Chapter 90 Adenosine Augmentation Therapy
- Index
(p. 618) Glia–Neuron Interactions in Ictogenesis and Epileptogenesis: Role of Inflammatory Mediators
- Chapter:
- (p. 618) Glia–Neuron Interactions in Ictogenesis and Epileptogenesis: Role of Inflammatory Mediators
- Author(s):
Annamaria Vezzani
, Stephan Auvin
, Teresa Ravizza
, and Eleonora Aronica
- DOI:
- 10.1093/med/9780199746545.003.0048
This chapter reports clinical observations in drug-resistant epilepsies and experimental findings in adult and immature rodent models of seizures and epileptogenesis that causally link brain inflammation to the epileptic process. We discuss the role of specific inflammatory mediators of glia–neuron communication in the etiopathogenesis of seizures.
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- Editorial Advisory Board
- Dedication
- Preface
- Acknowledgments
- Contributors
- Chapter 1 The Next Decade of Research in the Basic Mechanisms of the Epilepsies
- Chapter 2 Herbert H. Jasper and the Basic Mechanisms of the Epilepsies
- Chapter 3 Why—and How—Do We Approach Basic Epilepsy Research?
- Chapter 4 Voltage-Gated Na+ Channels
- Chapter 5 Potassium Channels (Including KCNQ) and Epilepsy
- Chapter 6 Voltage-Gated Calcium Channels in Epilepsy
- Chapter 7 Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy
- Chapter 8 Phasic GABAA-Mediated Inhibition
- Chapter 9 Tonic GABAA Receptor–Mediated Signaling in Epilepsy
- Chapter 10 Glutamatergic Mechanisms Related to Epilepsy
- Chapter 11 Glutamate Receptors in Epilepsy
- Chapter 12 Plasticity of Glutamate Synaptic Mechanisms
- Chapter 13 Neuronal Synchronization and Thalamocortical Rhythms during Sleep, Wake, and Epilepsy
- Chapter 14 Limbic Network Synchronization and Temporal Lobe Epilepsy
- Chapter 15 Imaging of Hippocampal Circuits in Epilepsy
- Chapter 16 Normal and Pathological High-Frequency Oscillations
- Chapter 17 Interictal Epileptiform Discharges in Partial Epilepsy
- Chapter 18 GABAA Receptor Function in Typical Absence Seizures
- Chapter 19 GABAB Receptor and Absence Epilepsy
- Chapter 20 Brainstem Networks
- Chapter 21 On the Basic Mechanisms of Infantile Spasms
- Chapter 22 Fast Oscillations and Synchronization Examined with In Vitro Models of Epileptogenesis
- Chapter 23 Computer Modeling of Epilepsy
- Chapter 24 Traumatic Brain Injury and Posttraumatic Epilepsy
- Chapter 25 Head Trauma and Epilepsy
- Chapter 26 Fever, Febrile Seizures, and Epileptogenesis
- Chapter 27 Role of Blood-Brain Barrier Dysfunction in Epileptogenesis
- Chapter 28 Cell Death and Survival Mechanisms after Single and Repeated Brief Seizures
- Chapter 29 Programmed Necrosis after Status Epilepticus
- Chapter 30 Histopathology of Human Epilepsy
- Chapter 31 The Time Course and Circuit Mechanisms of Acquired Epileptogenesis
- Chapter 32 Mossy Fiber Sprouting in the Dentate Gyrus
- Chapter 33 Kainate and Temporal Lobe Epilepsies
- Chapter 34 Abnormal Dentate Gyrus Network Circuitry in Temporal Lobe Epilepsy
- Chapter 35 Alterations in Synaptic Function in Epilepsy
- Chapter 36 Seizure-Induced Formation of Basal Dendrites on Granule Cells of the Rodent Dentate Gyrus
- Chapter 37 Perturbations of Dendritic Excitability in Epilepsy
- Chapter 38 Neurogenesis and Epilepsy
- Chapter 39 Temporal Lobe Epilepsy and the BDNF Receptor, TrkB
- Chapter 40 Alterations in the Distribution of GABAA Receptors in Epilepsy
- Chapter 41 GABAA Receptor Plasticity during Status Epilepticus
- Chapter 42 Plasticity of GABAA Receptors Relevant to Neurosteroid Actions
- Chapter 43 GABAA Receptor Plasticity in Alcohol Withdrawal
- Chapter 44 Regulation of GABAA Receptor Gene Expression and Epilepsy
- Chapter 45 Chloride Homeostasis and GABA Signaling in Temporal Lobe Epilepsy
- Chapter 46 Astrocytes and Epilepsy
- Chapter 47 Astrocyte Dysfunction in Epilepsy
- Chapter 48 Glia–Neuron Interactions in Ictogenesis and Epileptogenesis
- Chapter 49 Glia–Neuron Interactions
- Chapter 50 Genetic Epidemiology and Gene Discovery in Epilepsy
- Chapter 51 Strategies for Studying the Epilepsy Genome
- Chapter 52 Sodium Channel Mutations and Epilepsy
- Chapter 53 Potassium Channelopathies of Epilepsy
- Chapter 54 The Voltage-Gated Calcium Channel and Absence Epilepsy
- Chapter 55 Mutated GABAA Receptor Subunits in Idiopathic Generalized Epilepsy
- Chapter 56 The GABAAγ2(R43Q) Mouse Model of Human Genetic Epilepsy
- Chapter 57 GABAA Receptor Subunit Mutations and Genetic Epilepsies
- Chapter 58 Nicotinic Acetylcholine Receptor Mutations
- Chapter 59 Gene Interactions and Modifiers in Epilepsy
- Chapter 60 Rare Genetic Causes of Lissencephaly May Implicate Microtubule-Based Transport in the Pathogenesis of Cortical Dysplasias
- Chapter 61 The Generation of Cortical Interneurons
- Chapter 62 Genes in Infantile Epileptic Encephalopathies
- Chapter 63 Developing Models of Aristaless-Related Homeobox Mutations
- Chapter 64 Haploinsufficiency of STXBP1 and Ohtahara Syndrome
- Chapter 65 mTOR and Epileptogenesis in Developmental Brain Malformations
- Chapter 66 Major Susceptibility Genes for Common Idiopathic Epilepsies
- Chapter 67 Myoclonin1/EFHC1 in Cell Division, Neuroblast Migration, and Synapse/Dendrite Formation in Juvenile Myoclonic Epilepsy
- Chapter 68 Progressive Myoclonus Epilepsy of Lafora
- Chapter 69 Progressive Myoclonus Epilepsy
- Chapter 70 GABRB3, Epilepsy, and Neurodevelopment
- Chapter 71 Pathophysiology of Epilepsy in Autism Spectrum Disorders
- Chapter 72 Cognitive and Behavioral Comorbidities of Epilepsy
- Chapter 73 Migraine and Epilepsy—Shared Mechanisms within the Family of Episodic Disorders
- Chapter 74 Neurobiology of Depression as a Comorbidity of Epilepsy
- Chapter 75 Calcium Channel α2δ Subunits in Epilepsy and as Targets for Antiepileptic Drugs
- Chapter 76 Targeting SV2A for Discovery of Antiepileptic Drugs
- Chapter 77 Neurosteroids—Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy
- Chapter 78 Mechanisms of Ketogenic Diet Action
- Chapter 79 Deep Brain Stimulation for Epilepsy
- Chapter 80 Animal Models for Evaluating Antiepileptogenesis
- Chapter 81 Strategies for Antiepileptogenesis
- Chapter 82 Neonatal Seizures and Neuronal Transmembrane Ion Transport
- Chapter 83 Antiepileptogenesis, Plasticity of AED Targets, Drug Resistance, and Targeting the Immature Brain
- Chapter 84 Drug Resistance
- Chapter 85 Neural Stem Cell Therapy for Temporal Lobe Epilepsy
- Chapter 86 Embryonic Stem Cell Therapy for Intractable Epilepsy
- Chapter 87 Cell Therapy Using GABAergic Neural Progenitors
- Chapter 88 Reversing Disorders of Neuronal Migration and Differentiation in Animal Models
- Chapter 89 Gene Therapy of Focal-Onset Epilepsy Using Adeno-Associated Virus Vector-Mediated Overexpression of Neuropeptide Y
- Chapter 90 Adenosine Augmentation Therapy
- Index